With hubs in Los Angeles, Portland, Seattle, San Francisco, and Anchorage, Alaska Airlines carries more passengers between Alaska and the lower 48 states than any other airline. In 2023 alone, the airline served more than 35 million travelers. Alaska Airlines also operates out of focus cities San Diego, Boise, and San Jose, with over 100 destinations in the U.S., Canada, Mexico, Costa Rica, Belize, the Bahamas, and Guatemala. If you're flying with Alaska Airlines, consult Travel + Leisure's coverage to learn about cheap flights, onboard options, and more.