My Bibliography

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Hoang J, Gilbertson-White S, Cady N, Yadav M, Shahi S, Aguilar L, Mangalam AK, Cherwin C. Preliminary Analysis of Gut Microbiome and Gastrointestinal Symptom Burden in Breast Cancer Patients Receiving Chemotherapy Compared to Healthy Controls. Biol Res Nurs. 2024 Apr;26(2):219-230. doi: 10.1177/10998004231205277. Epub 2023 Oct 13. PubMed PMID: 37830211.

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Lehman PC, Ghimire S, Price JD, Ramer-Tait AE, Mangalam AK. Diet-microbiome-immune interplay in multiple sclerosis: Understanding the impact of phytoestrogen metabolizing gut bacteria. Eur J Immunol. 2023 Nov;53(11):e2250236. doi: 10.1002/eji.202250236. Epub 2023 Sep 13. Review. PubMed PMID: 37673213.

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Rashid F, Ghimire S, Mangalam AK, Giri S. A UPLC-MS/MS Based Rapid, Sensitive, and Non-Enzymatic Methodology for Quantitation of Dietary Isoflavones in Biological Fluids. Molecules. 2023 Sep 21;28(18). doi: 10.3390/molecules28186729. PubMed PMID: 37764503; PubMed Central PMCID: PMC10534480.

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Shrode RL, Ollberding NJ, Mangalam AK. Looking at the Full Picture: Utilizing Topic Modeling to Determine Disease-Associated Microbiome Communities. bioRxiv. 2023 Jul 25;. doi: 10.1101/2023.07.21.549984. PubMed PMID: 37546903; PubMed Central PMCID: PMC10401927.

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Mendoza-León MJ, Mangalam AK, Regaldiz A, González-Madrid E, Rangel-Ramírez MA, Álvarez-Mardonez O, Vallejos OP, Méndez C, Bueno SM, Melo-González F, Duarte Y, Opazo MC, Kalergis AM, Riedel CA. Gut microbiota short-chain fatty acids and their impact on the host thyroid function and diseases. Front Endocrinol (Lausanne). 2023;14:1192216. doi: 10.3389/fendo.2023.1192216. eCollection 2023. Review. PubMed PMID: 37455925; PubMed Central PMCID: PMC10349397.

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Lehman PC, Cady N, Ghimire S, Shahi SK, Shrode RL, Lehmler HJ, Mangalam AK. Low-dose glyphosate exposure alters gut microbiota composition and modulates gut homeostasis. Environ Toxicol Pharmacol. 2023 Jun;100:104149. doi: 10.1016/j.etap.2023.104149. Epub 2023 May 15. PubMed PMID: 37196884; PubMed Central PMCID: PMC10330715.

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Peterson SR, Ali S, Shrode RL, Mangalam AK. Effect of a Fructose-Rich Diet on Gut Microbiota and Immunomodulation: Potential Factors for Multiple Sclerosis. Immunohorizons. 2023 Mar 1;7(3):213-227. doi: 10.4049/immunohorizons.2300008. PubMed PMID: 36939622; PubMed Central PMCID: PMC10240966.

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Shrode RL, Knobbe JE, Cady N, Yadav M, Hoang J, Cherwin C, Curry M, Garje R, Vikas P, Sugg S, Phadke S, Filardo E, Mangalam AK. Breast cancer patients from the Midwest region of the United States have reduced levels of short-chain fatty acid-producing gut bacteria. Sci Rep. 2023 Jan 11;13(1):526. doi: 10.1038/s41598-023-27436-3. PubMed PMID: 36631533; PubMed Central PMCID: PMC9834383.

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Shrode RL, Cady N, Jensen SN, Borcherding N, Mangalam AK. Isoflavone consumption reduces inflammation through modulation of phenylalanine and lipid metabolism. Metabolomics. 2022 Oct 26;18(11):84. doi: 10.1007/s11306-022-01944-1. PubMed PMID: 36289122; PubMed Central PMCID: PMC10148689.

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Shahi SK, Ghimire S, Lehman P, Mangalam AK. Obesity induced gut dysbiosis contributes to disease severity in an animal model of multiple sclerosis. Front Immunol. 2022;13:966417. doi: 10.3389/fimmu.2022.966417. eCollection 2022. PubMed PMID: 36164343; PubMed Central PMCID: PMC9509138.

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Zahoor I, Suhail H, Datta I, Ahmed ME, Poisson LM, Waters J, Rashid F, Bin R, Singh J, Cerghet M, Kumar A, Hoda MN, Rattan R, Mangalam AK, Giri S. Blood-based untargeted metabolomics in relapsing-remitting multiple sclerosis revealed the testable therapeutic target. Proc Natl Acad Sci U S A. 2022 Jun 21;119(25):e2123265119. doi: 10.1073/pnas.2123265119. Epub 2022 Jun 14. PubMed PMID: 35700359; PubMed Central PMCID: PMC9231486.

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Yadav M, Ali S, Shrode RL, Shahi SK, Jensen SN, Hoang J, Cassidy S, Olalde H, Guseva N, Paullus M, Cherwin C, Wang K, Cho T, Kamholz J, Mangalam AK. Multiple sclerosis patients have an altered gut mycobiome and increased fungal to bacterial richness. PLoS One. 2022;17(4):e0264556. doi: 10.1371/journal.pone.0264556. eCollection 2022. PubMed PMID: 35472144; PubMed Central PMCID: PMC9041819.

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Simonsen D, Cady N, Zhang C, Shrode RL, McCormick ML, Spitz DR, Chimenti MS, Wang K, Mangalam A, Lehmler HJ. The Effects of Benoxacor on the Liver and Gut Microbiome of C57BL/6 Mice. Toxicol Sci. 2022 Feb 28;186(1):102-117. doi: 10.1093/toxsci/kfab142. PubMed PMID: 34850242; PubMed Central PMCID: PMC9019840.

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Mangalam AK, Giri S. Role of microbiome and metabolome in the pathobiology of MS. Clin Immunol. 2022 Feb;235:108934. doi: 10.1016/j.clim.2022.108934. Epub 2022 Jan 20. PubMed PMID: 35066173.

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Sugiura A, Andrejeva G, Voss K, Heintzman DR, Xu X, Madden MZ, Ye X, Beier KL, Chowdhury NU, Wolf MM, Young AC, Greenwood DL, Sewell AE, Shahi SK, Freedman SN, Cameron AM, Foerch P, Bourne T, Garcia-Canaveras JC, Karijolich J, Newcomb DC, Mangalam AK, Rabinowitz JD, Rathmell JC. MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function. Immunity. 2022 Jan 11;55(1):65-81.e9. doi: 10.1016/j.immuni.2021.10.011. Epub 2021 Nov 11. PubMed PMID: 34767747; PubMed Central PMCID: PMC8755618.

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Marietta E, Horwath I, Meyer S, Khaleghi-Rostamkolaei S, Norman E, Luckey D, Balakrishnan B, Mangalam A, Choung RS, Taneja V, Murray JA. Administration of Human Derived Upper gut Commensal Prevotella histicola delays the onset of type 1 diabetes in NOD mice. BMC Microbiol. 2022 Jan 4;22(1):8. doi: 10.1186/s12866-021-02406-9. PubMed PMID: 34983374; PubMed Central PMCID: PMC8729070.

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Ghimire S, Cady NM, Lehman P, Peterson SR, Shahi SK, Rashid F, Giri S, Mangalam AK. Dietary Isoflavones Alter Gut Microbiota and Lipopolysaccharide Biosynthesis to Reduce Inflammation. Gut Microbes. 2022 Jan-Dec;14(1):2127446. doi: 10.1080/19490976.2022.2127446. PubMed PMID: 36179318; PubMed Central PMCID: PMC9542810.

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Aggarwal N, Deerhake ME, DiPalma D, Shahi SK, Gaggioli MR, Mangalam AK, Shinohara ML. Secreted osteopontin from CD4(+) T cells limits acute graft-versus-host disease. Cell Rep. 2021 Dec 28;37(13):110170. doi: 10.1016/j.celrep.2021.110170. PubMed PMID: 34965439; PubMed Central PMCID: PMC8759344.

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Abu El Haija M, Ye Y, Chu Y, Herz H, Linden B, Shahi SK, Zarei K, Mangalam AK, Mcelroy SJ, Mokadem M. Toll-like receptor 4 and myeloid differentiation factor 88 are required for gastric bypass-induced metabolic effects. Surg Obes Relat Dis. 2021 Dec;17(12):1996-2006. doi: 10.1016/j.soard.2021.07.019. Epub 2021 Aug 2. PubMed PMID: 34462225; PubMed Central PMCID: PMC9083208.

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Jensen IJ, Jensen SN, McGonagill PW, Griffith TS, Mangalam AK, Badovinac VP. Autoimmunity Increases Susceptibility to and Mortality from Sepsis. Immunohorizons. 2021 Oct 26;5(10):844-854. doi: 10.4049/immunohorizons.2100070. PubMed PMID: 34702761; PubMed Central PMCID: PMC9036850.

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Mangalam AK. Fungal microbiome and multiple sclerosis: The not-so-new kid on the block. EBioMedicine. 2021 Oct;72:103621. doi: 10.1016/j.ebiom.2021.103621. Epub 2021 Oct 6. PubMed PMID: 34624688; PubMed Central PMCID: PMC8501652.

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Shahi SK, Ali S, Jaime CM, Guseva NV, Mangalam AK. HLA Class II Polymorphisms Modulate Gut Microbiota and Experimental Autoimmune Encephalomyelitis Phenotype. Immunohorizons. 2021 Aug 11;5(8):627-646. doi: 10.4049/immunohorizons.2100024. PubMed PMID: 34380664; PubMed Central PMCID: PMC8728531.

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Chau J, Yadav M, Liu B, Furqan M, Dai Q, Shahi S, Gupta A, Mercer KN, Eastman E, Hejleh TA, Chan C, Weiner GJ, Cherwin C, Lee STM, Zhong C, Mangalam A, Zhang J. Prospective correlation between the patient microbiome with response to and development of immune-mediated adverse effects to immunotherapy in lung cancer. BMC Cancer. 2021 Jul 13;21(1):808. doi: 10.1186/s12885-021-08530-z. PubMed PMID: 34256732; PubMed Central PMCID: PMC8278634.

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Jensen SN, Cady NM, Shahi SK, Peterson SR, Gupta A, Gibson-Corley KN, Mangalam AK. Isoflavone diet ameliorates experimental autoimmune encephalomyelitis through modulation of gut bacteria depleted in patients with multiple sclerosis. Sci Adv. 2021 Jul;7(28). doi: 10.1126/sciadv.abd4595. Print 2021 Jul. PubMed PMID: 34244137; PubMed Central PMCID: PMC8270496.

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Mangalam AK, Yadav M, Yadav R. The Emerging World of Microbiome in Autoimmune Disorders: Opportunities and Challenges. Indian J Rheumatol. 2021 Mar;16(1):57-72. doi: 10.4103/injr.injr_210_20. Epub 2021 Mar 23. PubMed PMID: 34531642; PubMed Central PMCID: PMC8442979.

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Shrader HR, Miller AM, Tomanek-Chalkley A, McCarthy A, Coleman KL, Ear PH, Mangalam AK, Salem AK, Chan CHF. Effect of bacterial contamination in bile on pancreatic cancer cell survival. Surgery. 2021 Mar;169(3):617-622. doi: 10.1016/j.surg.2020.09.029. Epub 2020 Oct 22. PubMed PMID: 33268071; PubMed Central PMCID: PMC7870517.

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Shahi SK, Jensen SN, Murra AC, Tang N, Guo H, Gibson-Corley KN, Zhang J, Karandikar NJ, Murray JA, Mangalam AK. Human Commensal Prevotella histicola Ameliorates Disease as Effectively as Interferon-Beta in the Experimental Autoimmune Encephalomyelitis. Front Immunol. 2020;11:578648. doi: 10.3389/fimmu.2020.578648. eCollection 2020. PubMed PMID: 33362764; PubMed Central PMCID: PMC7759500.

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Jensen IJ, Jensen SN, Sjaastad FV, Gibson-Corley KN, Dileepan T, Griffith TS, Mangalam AK, Badovinac VP. Sepsis impedes EAE disease development and diminishes autoantigen-specific naive CD4 T cells. Elife. 2020 Nov 16;9. doi: 10.7554/eLife.55800. PubMed PMID: 33191915; PubMed Central PMCID: PMC7721438.

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Marietta E, Mangalam AK, Taneja V, Murray JA. Intestinal Dysbiosis in, and Enteral Bacterial Therapies for, Systemic Autoimmune Diseases. Front Immunol. 2020;11:573079. doi: 10.3389/fimmu.2020.573079. eCollection 2020. Review. PubMed PMID: 33193357; PubMed Central PMCID: PMC7655733.

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Ye Y, Abu El Haija M, Morgan DA, Guo D, Song Y, Frank A, Tian L, Riedl RA, Burnett CML, Gao Z, Zhu Z, Shahi SK, Zarei K, Couvelard A, Poté N, Ribeiro-Parenti L, Bado A, Noureddine L, Bellizzi A, Kievit P, Mangalam AK, Zingman LV, Le Gall M, Grobe JL, Kaplan LM, Clegg D, Rahmouni K, Mokadem M. Endocannabinoid Receptor-1 and Sympathetic Nervous System Mediate the Beneficial Metabolic Effects of Gastric Bypass. Cell Rep. 2020 Oct 27;33(4):108270. doi: 10.1016/j.celrep.2020.108270. PubMed PMID: 33113371; PubMed Central PMCID: PMC7660289.

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Mangalam AK, Ochoa-Repáraz J. Editorial: The Role of the Gut Microbiota in Health and Inflammatory Diseases. Front Immunol. 2020;11:565305. doi: 10.3389/fimmu.2020.565305. eCollection 2020. PubMed PMID: 33042145; PubMed Central PMCID: PMC7527406.

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Cady N, Peterson SR, Freedman SN, Mangalam AK. Beyond Metabolism: The Complex Interplay Between Dietary Phytoestrogens, Gut Bacteria, and Cells of Nervous and Immune Systems. Front Neurol. 2020;11:150. doi: 10.3389/fneur.2020.00150. eCollection 2020. Review. PubMed PMID: 32231636; PubMed Central PMCID: PMC7083015.

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Shahi SK, Freedman SN, Dahl RA, Karandikar NJ, Mangalam AK. Scoring disease in an animal model of multiple sclerosis using a novel infrared-based automated activity-monitoring system. Sci Rep. 2019 Dec 16;9(1):19194. doi: 10.1038/s41598-019-55713-7. PubMed PMID: 31844134; PubMed Central PMCID: PMC6915774.

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Shahi SK, Zarei K, Guseva NV, Mangalam AK. Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing. J Vis Exp. 2019 Oct 15;(152). doi: 10.3791/59980. PubMed PMID: 31680682; PubMed Central PMCID: PMC6945761.

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Shahi SK, Freedman SN, Murra AC, Zarei K, Sompallae R, Gibson-Corley KN, Karandikar NJ, Murray JA, Mangalam AK. Prevotella histicola, A Human Gut Commensal, Is as Potent as COPAXONE® in an Animal Model of Multiple Sclerosis. Front Immunol. 2019;10:462. doi: 10.3389/fimmu.2019.00462. eCollection 2019. PubMed PMID: 30984162; PubMed Central PMCID: PMC6448018.

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Mangalam AK, Yadav R. Utility of CD64 Expression on Neutrophils as a Marker to Differentiate Infectious versus Noninfectious Disease Flares in Autoimmune Disorders. Indian J Rheumatol. 2019 Mar;14(1):9-11. doi: 10.4103/0973-3698.254192. Epub 2019 Mar 14. PubMed PMID: 31885420; PubMed Central PMCID: PMC6934104.

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Mangalam AK, Murray J. Microbial monotherapy with Prevotella histicola for patients with multiple sclerosis. Expert Rev Neurother. 2019 Jan;19(1):45-53. doi: 10.1080/14737175.2019.1555473. Epub 2018 Dec 10. Review. PubMed PMID: 30513004; PubMed Central PMCID: PMC6548683.

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Strouse C, Mangalam A, Zhang J. Bugs in the system: bringing the human microbiome to bear in cancer immunotherapy. Gut Microbes. 2019;10(2):109-112. doi: 10.1080/19490976.2018.1511665. Epub 2018 Sep 5. PubMed PMID: 30183502; PubMed Central PMCID: PMC6546317.

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Mangalam AK. Drugs, bugs, and MS: The interplay between disease-modifying therapy and gut microbiota. Neurol Neuroimmunol Neuroinflamm. 2019 Jan;6(1):e524. doi: 10.1212/NXI.0000000000000524. eCollection 2019 Jan. PubMed PMID: 30569001; PubMed Central PMCID: PMC6278853.

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Marietta E, Mangalam A, Murray J, Taneja V. Reply. Arthritis Rheumatol. 2018 Feb;70(2):321-322. doi: 10.1002/art.40331. Epub 2017 Dec 15. PubMed PMID: 28950432.

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Freedman SN, Shahi SK, Mangalam AK. The "Gut Feeling": Breaking Down the Role of Gut Microbiome in Multiple Sclerosis. Neurotherapeutics. 2018 Jan;15(1):109-125. doi: 10.1007/s13311-017-0588-x. Review. PubMed PMID: 29204955; PubMed Central PMCID: PMC5794701.

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Shahi SK, Freedman SN, Mangalam AK. Gut microbiome in multiple sclerosis: The players involved and the roles they play. Gut Microbes. 2017 Nov 2;8(6):607-615. doi: 10.1080/19490976.2017.1349041. Epub 2017 Aug 3. Review. PubMed PMID: 28696139; PubMed Central PMCID: PMC5730390.

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Mangalam A, Shahi SK, Luckey D, Karau M, Marietta E, Luo N, Choung RS, Ju J, Sompallae R, Gibson-Corley K, Patel R, Rodriguez M, David C, Taneja V, Murray J. Human Gut-Derived Commensal Bacteria Suppress CNS Inflammatory and Demyelinating Disease. Cell Rep. 2017 Aug 8;20(6):1269-1277. doi: 10.1016/j.celrep.2017.07.031. PubMed PMID: 28793252; PubMed Central PMCID: PMC5763484.

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Zhao J, Alshukairi AN, Baharoon SA, Ahmed WA, Bokhari AA, Nehdi AM, Layqah LA, Alghamdi MG, Al Gethamy MM, Dada AM, Khalid I, Boujelal M, Al Johani SM, Vogel L, Subbarao K, Mangalam A, Wu C, Ten Eyck P, Perlman S, Zhao J. Recovery from the Middle East respiratory syndrome is associated with antibody and T-cell responses. Sci Immunol. 2017 Aug 4;2(14). doi: 10.1126/sciimmunol.aan5393. Epub 2017 Aug 4. PubMed PMID: 28778905; PubMed Central PMCID: PMC5576145.

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Marietta EV, Murray JA, Luckey DH, Jeraldo PR, Lamba A, Patel R, Luthra HS, Mangalam A, Taneja V. Suppression of Inflammatory Arthritis by Human Gut-Derived Prevotella histicola in Humanized Mice. Arthritis Rheumatol. 2016 Dec;68(12):2878-2888. doi: 10.1002/art.39785. PubMed PMID: 27337150; PubMed Central PMCID: PMC5125894.

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Wang Y, Cao Y, Mangalam AK, Guo Y, LaFrance-Corey RG, Gamez JD, Atanga PA, Clarkson BD, Zhang Y, Wang E, Angom RS, Dutta K, Ji B, Pirko I, Lucchinetti CF, Howe CL, Mukhopadhyay D. Neuropilin-1 modulates interferon-γ-stimulated signaling in brain microvascular endothelial cells. J Cell Sci. 2016 Oct 15;129(20):3911-3921. doi: 10.1242/jcs.190702. Epub 2016 Sep 2. PubMed PMID: 27591257; PubMed Central PMCID: PMC5087664.

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Mangalam AK, Rattan R, Suhail H, Singh J, Hoda MN, Deshpande M, Fulzele S, Denic A, Shridhar V, Kumar A, Viollet B, Rodriguez M, Giri S. AMP-Activated Protein Kinase Suppresses Autoimmune Central Nervous System Disease by Regulating M1-Type Macrophage-Th17 Axis. J Immunol. 2016 Aug 1;197(3):747-60. doi: 10.4049/jimmunol.1501549. Epub 2016 Jun 27. PubMed PMID: 27354217.

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Chen J, Chia N, Kalari KR, Yao JZ, Novotna M, Paz Soldan MM, Luckey DH, Marietta EV, Jeraldo PR, Chen X, Weinshenker BG, Rodriguez M, Kantarci OH, Nelson H, Murray JA, Mangalam AK. Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls. Sci Rep. 2016 Jun 27;6:28484. doi: 10.1038/srep28484. PubMed PMID: 27346372; PubMed Central PMCID: PMC4921909.

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Zhao J, Zhao J, Mangalam AK, Channappanavar R, Fett C, Meyerholz DK, Agnihothram S, Baric RS, David CS, Perlman S. Airway Memory CD4(+) T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses. Immunity. 2016 Jun 21;44(6):1379-91. doi: 10.1016/j.immuni.2016.05.006. Epub 2016 Jun 7. PubMed PMID: 27287409; PubMed Central PMCID: PMC4917442.

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Poisson LM, Suhail H, Singh J, Datta I, Denic A, Labuzek K, Hoda MN, Shankar A, Kumar A, Cerghet M, Elias S, Mohney RP, Rodriguez M, Rattan R, Mangalam AK, Giri S. Untargeted Plasma Metabolomics Identifies Endogenous Metabolite with Drug-like Properties in Chronic Animal Model of Multiple Sclerosis. J Biol Chem. 2015 Dec 25;290(52):30697-712. doi: 10.1074/jbc.M115.679068. Epub 2015 Nov 6. PubMed PMID: 26546682; PubMed Central PMCID: PMC4692201.