Featured Research Program
X-Ray Irradiator / X-Ray Imaging / Bioluminescent Imaging (David Wald PhD)
The X-Rad 320 X-ray irradiator from Precision X-ray Inc. is a large chamber self-contained X-ray system that enables the delivery of precise radiation doses to small animals, biological specimens, and reagents. This instrument incorporates an anesthesia system and has the capability to perform bioluminescent imaging and X-ray imaging. This unique dual capability allows for tracking cells and disease progression in mice over time. The irradiator is currently housed in the Animal Research Facility as a Core instrument.
A major reason for our purchasing this instrument was to irradiate small animals such as mice, to enable the transplant of allogeneic cells (e.g., bone marrow transplants or human tumor cells). The irradiator can also be used to irradiate cell cultures, feeder cell layers, bacteria, and viruses. In cell culture models, this irradiation can be used to generate mutations as well as to study the effects of radiation exposure on cells. In addition, the irradiator can be used to sterilize reagents, particularly those that cannot be autoclaved. Of note, the irradiator has been used to inactivate SARSCOV- 2 virus in biological specimens as well as to sterile PPE.
This instrument has significant safety and security advantages in comparison to other X-ray irradiators. The X-RAD 320 X-ray irradiator is a non-radioactive alternative to the commonly used Cesium-137 radioactive irradiators. In comparison, to Cesium-137 irradiators this instrument is easier to use and will provide consistent throughput of irradiation over its lifespan.
Research Forums
Research forums will be held monthly at the VA in Room K119. Our summer/fall schedule for forums are listed below. We encourage you to attend in person if you can. If you are unavailable to attend in person, you will have the option to view the presentation via Teams.
Please note: We will not have a Research Forum for August!
Tuesday, September 19th @ 1:00pm
Modifications and Closures with IRB: presented by, Jacqueline Charles, IRB Administrator & Joy Volpi IRB Coordinator
Microsoft Teams meeting; Join on your computer, mobile app or room device
Meeting ID: 233 432 423 153 Passcode: YEoxU5
Or call in (audio only)
+1 872-701-0185,,449747075# United States, Chicago
Phone Conference ID: 449 747 075#
Click here to join the meeting
Tuesday, September 28th @ 1:00pm
How to Find/Manage Your Documents in IRBNet: presented by Christina Bennett, Health System Specialist
Tuesday, October 17th @ 1:00pm
Continuing Reviews with the Safety Committee: presented by, John Schaffer, Research Safety Coordinator
IRB Office
Jonathan Filicko has been selected to fill the vacant IRB Coordinator position. Jonathan started on Monday, July 31. Most recently Jonathan worked at the UH Seidman Cancer Center and prior to that he was with the DOD Bone Marrow Donor Program. Welcome Jonathan!
Office Hours (Research Compliance & Education)
Research Compliance Office & Research Service (Education) have an open forum via teams the 2nd & 4th Friday of each month from 12:30pm-1:00pm
Our next office hours is scheduled for Friday, August 18th. We will be discussing the Informed Consent Audit Process
If you have a topics that you would like for us to discuss in future office hours, please feel free to send an email to candice.toney@va.gov
Please use the link below to join us. The office hours are recorded if you are unable to attend.
Join on your computer, mobile app or room device
Click here to join the meeting
Meeting ID: 272 015 014 191 Passcode: kDx3KT
VA REDCap is now approved for storage of PHI & PII and has public-facing survey capability.
VA REDCap log-in remains available on the VA network only. However, respondents outside the VA can now use a VA REDCap survey link from any internet-connected device. For example, you can now scan the QR code to a VA REDCap survey link from your personal phone. The links below provide more information. These links are accessible only when logged onto the VA network.
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Request an account by filling out a VA REDCap Ticket.
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Review the VA REDCap Guidelines to learn about the responsibilities of VA REDCap account holders.
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Visit "FAQs page" for answers to commonly asked questions about using VA REDCap.
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Join VA REDCap Hour, an open question and answer time with members of the VA REDCap support team. They meet every Thursday from 3-4pm Eastern Time on Microsoft Teams. Click here to join the meeting.
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Still not sure where to start? Contact VIReCREDCapSupport@va.gov for more information about using VA REDCap.
Study Initiation Visits
What is a Study Initiation Visit?
The study initiation visit encompasses a review of regulatory requirements as they apply to your specific study, good clinical practice guidelines, the informed consent and HIPAA documents as well as a review of how to maintain study records (regulatory binder and subject files).
The Research Compliance Office is required to perform a triennial regulatory audit of studies (human subjects' research, animal protocols, and basic science studies) and informed consent and HIPAA audits if applicable. The intent of a study initiation visit is to help the researcher avoid the most common audit findings before they occur.
Did you know that you can schedule a Study Initiation Visit with the Research Service?
The study initiation visit is available to all research staff. If you are new to research or need a refresher, you can schedule a study initiation visit today.
For scheduling or questions contact Candice Toney at Candice.Toney@va.gov or 216-791-3800 x66785
Upcoming VA Research Funding Deadlines
VA BLR&D, CSR&D and RR&D SPiRE funding applications will be submitted in September. if you are planning to submit a grant application this upcoming Fall cycle, please contact Joe Bennett (Joseph.Bennett2@va.gov).
All submissions must be reviewed and approved by the R&D Committee prior to submitting. See below.
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R&DC Submission Deadline
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Meeting Date
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August 8
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August 17 (This is the last meeting for NEW submissions)
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August 29
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September 7 (Only resubmissions will be reviewed at this meeting)
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Office of Research & Development
Upcoming Webinars: Office of Research Protections, Policy, and Education Webinars (va.gov)
Tuesday, August 15, 2023 1:00 PM - 2:00 PM
VAIRRS Monthly Webinar Series: New Wizards registration - VA WebEx Enterprise Site
Archived webinars can be found at: ORPP&E Webinar Archive (va.gov)
Stay Connected
VA Northeast Ohio Healthcare System
Cleveland Research Website
Office of Research & Development
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