Rat Model of Type 2 Diabetes Mellitus Recapitulates Human Disease in the Anterior Segment of the Eye.
Am J Pathol.
2024 Feb 24;. doi: 10.1016/j.ajpath.2024.02.004. [Epub ahead of print] PubMed PMID:
38403162.
Calpain inhibition protects against atrial fibrillation by mitigating diabetes-associated atrial fibrosis and calcium handling dysfunction in type 2 diabetes mice.
Heart Rhythm.
2024 Feb 21;. doi: 10.1016/j.hrthm.2024.02.036. [Epub ahead of print] PubMed PMID:
38395244.
Biology of Activating Transcription Factor 4 (ATF4) and Its Role in Skeletal Muscle Atrophy.
J Nutr.
2022 Apr 1;152(4):926-938. doi: 10.1093/jn/nxab440. Review. PubMed PMID:
34958390; PubMed Central PMCID:
PMC8970988.
Treatment for Diabetic Peripheral Neuropathy: What have we Learned from Animal Models?.
Curr Diabetes Rev.
2022;18(5):e040521193121. doi: 10.2174/1573399817666210504101609. Review. PubMed PMID:
33949936; PubMed Central PMCID:
PMC8965779.
COMPARATIVE EFFECT OF A HIGH FAT WITH OR WITHOUT HIGH LEVELS OF SUCROSE DIETS ON PERIPHERAL NEUROPATHY IN C57BL/6J MICE.
J Diabet Complicat Ther.
2022;1(1). PubMed PMID:
37332358; PubMed Central PMCID:
PMC10274354.
Distinct properties of Ca(2+) efflux from brain, heart and liver mitochondria: The effects of Na(+), Li(+) and the mitochondrial Na(+)/Ca(2+) exchange inhibitor CGP37157.
Cell Calcium.
2021 Jun;96:102382. doi: 10.1016/j.ceca.2021.102382. Epub 2021 Feb 22. PubMed PMID:
33684833; PubMed Central PMCID:
PMC8187304.
Stay or go? Neuronal activity in medial frontal cortex during a voluntary tactile preference task in head-fixed mice.
Cell Calcium.
2021 Jun;96:102388. doi: 10.1016/j.ceca.2021.102388. Epub 2021 Mar 4. PubMed PMID:
33740531; PubMed Central PMCID:
PMC8224542.
COMPARATIVE EFFECT OF A HIGH FAT WITH OR WITHOUT HIGH LEVELS OF SUCROSE DIETS ON PERIPHERAL NEUROPATHY IN C57BL/6J MICE.
Journal of Diabetic Complications & Therapy. 2021 April; 1(1).
Characterization of Mice Ubiquitously Overexpressing Human 15-Lipoxygenase-1: Effect of Diabetes on Peripheral Neuropathy and Treatment with Menhaden Oil.
J Diabetes Res.
2021;2021:5564477. doi: 10.1155/2021/5564477. eCollection 2021. PubMed PMID:
33816635; PubMed Central PMCID:
PMC7987465.
Effect of mitoquinone on liver metabolism and steatosis in obese and diabetic rats.
Pharmacol Res Perspect.
2021 Feb;9(1):e00701. doi: 10.1002/prp2.701. PubMed PMID:
33547885; PubMed Central PMCID:
PMC7866483.
Interaction between magnesium and methylglyoxal in diabetic polyneuropathy and neuronal models.
Mol Metab.
2021 Jan;43:101114. doi: 10.1016/j.molmet.2020.101114. Epub 2020 Nov 6. PubMed PMID:
33166742; PubMed Central PMCID:
PMC7704399.
Insulin Treatment Attenuates Small Nerve Fiber Damage in Rat Model of Type 2 Diabetes.
J Diabetes Res.
2020;2020:9626398. doi: 10.1155/2020/9626398. eCollection 2020. PubMed PMID:
32832565; PubMed Central PMCID:
PMC7424504.
Effect of mitoquinone (Mito-Q) on neuropathic endpoints in an obese and type 2 diabetic rat model.
Free Radic Res.
2020 May;54(5):311-318. doi: 10.1080/10715762.2020.1754409. Epub 2020 Apr 24. PubMed PMID:
32326763; PubMed Central PMCID:
PMC7329571.
Progressive Loss of Corneal Nerve Fibers and Sensitivity in Rats Modeling Obesity and Type 2 Diabetes Is Reversible with Omega-3 Fatty Acid Intervention: Supporting Cornea Analyses as a Marker for Peripheral Neuropathy and Treatment.
Diabetes Metab Syndr Obes.
2020;13:1367-1384. doi: 10.2147/DMSO.S247571. eCollection 2020. PubMed PMID:
32425569; PubMed Central PMCID:
PMC7189026.
Deletion of a Neuronal Drp1 Activator Protects against Cerebral Ischemia.
J Neurosci.
2020 Apr 8;40(15):3119-3129. doi: 10.1523/JNEUROSCI.1926-19.2020. Epub 2020 Mar 6. PubMed PMID:
32144179; PubMed Central PMCID:
PMC7141887.
Effect of Early and Late Interventions with Dietary Oils on Vascular and Neural Complications in a Type 2 Diabetic Rat Model.
J Diabetes Res.
2019;2019:5020465. doi: 10.1155/2019/5020465. eCollection 2019. PubMed PMID:
31485451; PubMed Central PMCID:
PMC6702827.
Determination of peripheral neuropathy in high-fat diet fed low-dose streptozotocin-treated female C57Bl/6J mice and Sprague-Dawley rats.
J Diabetes Investig.
2018 Sep;9(5):1033-1040. doi: 10.1111/jdi.12814. Epub 2018 Mar 25. PubMed PMID:
29412513; PubMed Central PMCID:
PMC6123046.
The Potential Role of Fatty Acids in Treating Diabetic Neuropathy.
Curr Diab Rep.
2018 Aug 25;18(10):86. doi: 10.1007/s11892-018-1046-9. Review. PubMed PMID:
30145729; PubMed Central PMCID:
PMC6816026.
Dietary fats modify vascular fat composition, eNOS localization within lipid rafts and vascular function in obesity.
Physiol Rep.
2018 Aug;6(15):e13820. doi: 10.14814/phy2.13820. PubMed PMID:
30105819; PubMed Central PMCID:
PMC6090220.
Vascular and Neural Complications in Type 2 Diabetic Rats: Improvement by Sacubitril/Valsartan Greater Than Valsartan Alone.
Diabetes.
2018 Aug;67(8):1616-1626. doi: 10.2337/db18-0062. Epub 2018 Jun 25. PubMed PMID:
29941448.
Effect of Dietary Content of Menhaden Oil with or without Salsalate on Neuropathic Endpoints in High-Fat-Fed/Low-Dose Streptozotocin-Treated Sprague Dawley Rats.
J Diabetes Res.
2018;2018:2967127. doi: 10.1155/2018/2967127. eCollection 2018. PubMed PMID:
30057911; PubMed Central PMCID:
PMC6051246.
Effect of dietary oils on peripheral neuropathy-related endpoints in dietary obese rats.
Diabetes Metab Syndr Obes.
2018;11:117-127. doi: 10.2147/DMSO.S159071. eCollection 2018. PubMed PMID:
29674850; PubMed Central PMCID:
PMC5898889.
Is Fish Oil a Potential Treatment for Diabetic Peripheral Neuropathy?.
Curr Diabetes Rev.
2018;14(4):339-349. doi: 10.2174/1573399813666170522155327. Review. PubMed PMID:
28530530.
Effect of Fish Oil vs. Resolvin D1, E1, Methyl Esters of Resolvins D1 or D2 on Diabetic Peripheral Neuropathy.
J Neurol Neurophysiol.
2017;8(6). doi: 10.4172/2155-9562.1000453. Epub 2017 Dec 24. PubMed PMID:
29423332; PubMed Central PMCID:
PMC5800519.
Impaired Corneal Sensation and Nerve Loss in a Type 2 Rat Model of Chronic Diabetes Is Reversible With Combination Therapy of Menhaden Oil, α-Lipoic Acid, and Enalapril.
Cornea.
2017 Jun;36(6):725-731. doi: 10.1097/ICO.0000000000001182. PubMed PMID:
28476051; PubMed Central PMCID:
PMC5421399.
Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction.
Nat Med.
2017 Jun;23(6):753-762. doi: 10.1038/nm.4328. Epub 2017 Apr 24. PubMed PMID:
28436957; PubMed Central PMCID:
PMC5575773.
Effect of tempol on peripheral neuropathy in diet-induced obese and high-fat fed/low-dose streptozotocin-treated C57Bl6/J mice.
Free Radic Res.
2017 Apr;51(4):360-367. doi: 10.1080/10715762.2017.1315767. Epub 2017 Apr 19. PubMed PMID:
28376643; PubMed Central PMCID:
PMC5575770.
Early vs. late intervention of high fat/low dose streptozotocin treated C57Bl/6J mice with enalapril, α-lipoic acid, menhaden oil or their combination: Effect on diabetic neuropathy related endpoints.
Neuropharmacology.
2017 Apr;116:122-131. doi: 10.1016/j.neuropharm.2016.12.022. Epub 2016 Dec 23. PubMed PMID:
28025096; PubMed Central PMCID:
PMC5385152.
Effect of Inhibition or Deletion of Neutral Endopeptidase on Neuropathic Endpoints in High Fat Fed/Low Dose Streptozotocin-Treated Mice.
J Neuropathol Exp Neurol.
2016 Nov 1;75(11):1072-1080. doi: 10.1093/jnen/nlw083. PubMed PMID:
27634964; PubMed Central PMCID:
PMC7714044.
Effect of Treatment with Salsalate, Menhaden Oil, Combination of Salsalate and Menhaden Oil, or Resolvin D1 of C57Bl/6J Type 1 Diabetic Mouse on Neuropathic Endpoints.
J Nutr Metab.
2016;2016:5905891. doi: 10.1155/2016/5905891. Epub 2016 Sep 28. PubMed PMID:
27774316; PubMed Central PMCID:
PMC5059581.
Effect of Inhibition or Deletion of Neutral Endopeptidase on Neuropathic Endpoints in High Fat Fed/Low Dose Streptozotocin-Treated Mice.
Journal Neuropathology Experimental Neurology. 2016 September; 75(11):1072. doi: 10.1093/jnen/nlw083.
Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice.
Sci Rep.
2016 May 27;6:26933. doi: 10.1038/srep26933. PubMed PMID:
27230286; PubMed Central PMCID:
PMC4882590.
Corneal Sensitivity to Hyperosmolar Eye Drops: A Novel Behavioral Assay to Assess Diabetic Peripheral Neuropathy.
Invest Ophthalmol Vis Sci.
2016 May 1;57(6):2412-9. doi: 10.1167/iovs.16-19435. PubMed PMID:
27145474; PubMed Central PMCID:
PMC5113984.
Alternatives to the Streptozotocin-Diabetic Rodent.
Int Rev Neurobiol.
2016;127:89-112. doi: 10.1016/bs.irn.2016.03.002. Epub 2016 Mar 28. Review. PubMed PMID:
27133146; PubMed Central PMCID:
PMC5577923.
Effect of combination therapy consisting of enalapril, α-lipoic acid, and menhaden oil on diabetic neuropathy in a high fat/low dose streptozotocin treated rat.
Eur J Pharmacol.
2015 Oct 15;765:258-67. doi: 10.1016/j.ejphar.2015.08.015. Epub 2015 Aug 18. PubMed PMID:
26291662.
Vascular Impairment of Epineurial Arterioles of the Sciatic Nerve: Implications for Diabetic Peripheral Neuropathy.
Rev Diabet Stud.
2015 Spring-Summer;12(1-2):13-28. doi: 10.1900/RDS.2015.12.13. Epub 2015 Aug 10. Review. PubMed PMID:
26676659; PubMed Central PMCID:
PMC5397981.
Rat Models of Diet-Induced Obesity and High Fat/Low Dose Streptozotocin Type 2 Diabetes: Effect of Reversal of High Fat Diet Compared to Treatment with Enalapril or Menhaden Oil on Glucose Utilization and Neuropathic Endpoints.
J Diabetes Res.
2015;2015:307285. doi: 10.1155/2015/307285. Epub 2015 Jul 2. PubMed PMID:
26229968; PubMed Central PMCID:
PMC4503545.
Effect of enriching the diet with menhaden oil or daily treatment with resolvin D1 on neuropathy in a mouse model of type 2 diabetes.
J Neurophysiol.
2015 Jul;114(1):199-208. doi: 10.1152/jn.00224.2015. Epub 2015 Apr 29. PubMed PMID:
25925322; PubMed Central PMCID:
PMC4507972.
Role of Peroxynitrite in the Development of Diabetic Peripheral Neuropathy.
Diabetes Care.
2015 Jul;38(7):e100-1. doi: 10.2337/dc14-2918. PubMed PMID:
26106228; PubMed Central PMCID:
PMC5321249.
Effect of diet-induced obesity or type 1 or type 2 diabetes on corneal nerves and peripheral neuropathy in C57Bl/6J mice.
J Peripher Nerv Syst.
2015 Mar;20(1):24-31. doi: 10.1111/jns.12111. PubMed PMID:
25858759; PubMed Central PMCID:
PMC4470853.
Enriching the diet with menhaden oil improves peripheral neuropathy in streptozotocin-induced type 1 diabetic rats.
J Neurophysiol.
2015 Feb 1;113(3):701-8. doi: 10.1152/jn.00718.2014. Epub 2014 Nov 5. PubMed PMID:
25376787; PubMed Central PMCID:
PMC4312862.
Combination therapies prevent the neuropathic, proinflammatory characteristics of bone marrow in streptozotocin-induced diabetic rats.
Diabetes.
2015 Feb;64(2):643-53. doi: 10.2337/db14-0433. Epub 2014 Sep 9. PubMed PMID:
25204979; PubMed Central PMCID:
PMC4876792.
Peroxynitrite and protein nitration in the pathogenesis of diabetic peripheral neuropathy.
Diabetes Metab Res Rev.
2014 Nov;30(8):669-78. doi: 10.1002/dmrr.2549. PubMed PMID:
24687457; PubMed Central PMCID:
PMC4177961.
Characterization of diabetic neuropathy in the Zucker diabetic Sprague-Dawley rat: a new animal model for type 2 diabetes.
J Diabetes Res.
2014;2014:714273. doi: 10.1155/2014/714273. Epub 2014 Oct 13. PubMed PMID:
25371906; PubMed Central PMCID:
PMC4211210.
Effect of glycemic control on corneal nerves and peripheral neuropathy in streptozotocin-induced diabetic C57Bl/6J mice.
J Peripher Nerv Syst.
2014 Sep;19(3):205-17. doi: 10.1111/jns.12086. PubMed PMID:
25403729; PubMed Central PMCID:
PMC4986703.
Phenotyping animal models of diabetic neuropathy: a consensus statement of the diabetic neuropathy study group of the EASD (Neurodiab).
J Peripher Nerv Syst.
2014 Jun;19(2):77-87. doi: 10.1111/jns5.12072. Review. PubMed PMID:
24934510; PubMed Central PMCID:
PMC4303044.
Differences and similarities in development of corneal nerve damage and peripheral neuropathy and in diet-induced obesity and type 2 diabetic rats.
Invest Ophthalmol Vis Sci.
2014 Mar 3;55(3):1222-30. doi: 10.1167/iovs.13-13794. PubMed PMID:
24519423; PubMed Central PMCID:
PMC3941618.
12/15-Lipoxygenase inhibition counteracts MAPK phosphorylation in mouse and cell culture models of diabetic peripheral neuropathy.
J Diabetes Mellitus.
2013 Aug;3(3). doi: 10.4236/jdm.2013.33015. PubMed PMID:
24175152; PubMed Central PMCID:
PMC3808974.
Na+/H+ exchanger 1 inhibition reverses manifestation of peripheral diabetic neuropathy in type 1 diabetic rats.
Am J Physiol Endocrinol Metab.
2013 Aug 1;305(3):E396-404. doi: 10.1152/ajpendo.00186.2013. Epub 2013 Jun 4. PubMed PMID:
23736542; PubMed Central PMCID:
PMC3742852.
Modification of high saturated fat diet with n-3 polyunsaturated fat improves glucose intolerance and vascular dysfunction.
Diabetes Obes Metab.
2013 Feb;15(2):144-52. doi: 10.1111/dom.12004. Epub 2012 Sep 30. PubMed PMID:
22950668; PubMed Central PMCID:
PMC3674571.
What would you like to do?